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Trenbolone (Tren) is considered to be the most powerful androgenic-anabolic steroid (AAS) available, with an exceptionally high ratio of anabolic to androgenic effectsand low abuse liability (Benson, 1988; Höpfner et al., 1992; Lücke, 1998). However, recent data indicate that Tren has significant antiandrogenic effects in vitro and in rodents (Winkler, 1994). In contrast, the effects of Tren in vivo were not well characterized, a high dose considered is what of prednisone. Hence, in the present study, we investigated the effects of Tren on rat uterine androgen receptor gene expression after administration to pregnant rats of the high androgenic dose (5 mg/kg body wt.), a dose which is in the upper limit of the androgenic range (Ibid; Lebron et al., 2004). In a double-blind treatment protocol, the rats were divided into two groups, and animals were injected via the tail vein with 4 mg/kg Tren bolus and vehicle (vehicle only) or 4 mg/kg Tren bolus and vehicle alone, testo max x12 como tomar. The doses of Tren administered, and dose/time of Tren exposure, in animals that received Tren and vehicle are given in Table , testo max uae. Table 4 Duration of Tren exposure, mg Tren exposure in rats, min Tren dose in animals, μg/kg Tren dose in animals, h All doses and time intervals were expressed in mg/kg body wt. Groups of animals given saline Tren at various times in the drug treatment period; (A) 5 mg/kg; (B) 5, 10, 17, 25 and 45 days; (C) 5 mg/kg; (D) 5, 10 and 17 days; (E) 4 mg/kg.; (F) 5, 10, 18 and 30 days; (G) 4 mg/kg; (H) 5 and 10 days; (I) 27, 40, 55, 70, 85, 105, 125, 130 and 155 days; (J) 4 and 7 days; No animals were given drug at the end of the study (Ibid; Lebron et al, testo max uae., 2004), testo max uae. 4. Discussion and conclusions Tren has been suggested to counteract or retard the male sexual phenotype in some animal species, what is considered a high dose of prednisone. However, not much is known about its mechanisms of action in male rats. To assess the effects of testosterone on rats from different ages and sexes, the effects of 5 mg/kg doses of Tren on rat uterine androgen receptor (ER) gene expression was studied in animals treated with Tren and vehicle in the following study.
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